Harr Hematology Practice Test

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• What is the fundamental reason for using anti-Xa assays during LMWH therapy?
• What is indicated by normal PT, prolonged APTT, increased bleeding time, and normal platelet count?
• Which of the following features is NOT typically associated with Hgb C disease?
• What clinical manifestation is highly indicative of acute monocytic leukemia?
• Which of the following Hgb configurations is characteristic of Hgb H?
• An increased RDW on an electronic cell counter is correlated with which condition?
• What condition would be suspected if a patient has no bleeding complications but shows a prolonged APTT?
• What implication does a prolonged APTT have if it normalizes after mixing?
• What term describes the change in the shape of erythrocytes on a Wright's-stained peripheral blood smear?
• What is the correct ratio of anticoagulant to blood for coagulation procedures?
• Which of the following is NOT a characteristic finding in a patient with iron deficiency anemia?
• In which condition may peripheral blood smear show spherocytes?
• What is factor XIII's primary function in the clotting process?
• Which erythrocyte inclusion is detectable with supravital stain but not on a Wright's-stained blood smear?
• A prolonged APTT corrected with factor VIII-deficient plasma but not with factor IX-deficient plasma indicates which factor is deficient?
• What does lumi-aggregation measure in platelet function tests?
• Which of the following is associated with antithrombin deficiency?
• One of the complications associated with severe hemophilia A is:
• What does reticulocytosis usually indicate?
• Which statement is correct regarding sample storage for the prothrombin time test?
• Bernard-Soulier syndrome is associated with which of the following?
• What is the corrected reticulocyte count for a patient with a reticulocyte count of 7% and an Hct of 20%?
• Which antibiotic is most commonly associated with the development of aplastic anemia?
• What is the white blood cell (WBC) count when 36 cells are counted using a 1:10 dilution?
• Which of the following can shift the hemoglobin oxygen dissociation curve to the right?
• Which erythrocyte abnormality is characterized by an increased number of target cells?
• Which of the following occurs in idiopathic myelofibrosis?
• Which of the following results is characteristic of lupus anticoagulant in mixing studies?
• What is the characteristic abnormal red blood cell morphology in myelofibrosis?
• A 24-year-old man with Down syndrome presents with multiple symptoms and abnormal CBC results. What does this suggest?
• How does thrombotic thrombocytopenic purpura (TTP) differ from disseminated intravascular coagulation (DIC)?
• Which of the following is NOT a characteristic of hemolytic uremic syndrome (HUS)?
• Elevation of which substance is a risk factor for thrombotic events?
• Which morphological classification is characteristic of megaloblastic anemia?
• Which of the following drugs is a thrombolytic agent?
• Which of the following is associated with multiple factor deficiencies?
• In what condition is Argatroban primarily used as an anticoagulant?
• Which deficiency leads to macrocytic anemia?
• Which of the following is referred to as an endogenous activator of plasminogen?
• What is the preferred site for bone marrow aspiration and biopsy in adults?
• In a factor VIII activity assay, the patient's plasma should be mixed with what type of plasma?
• Which reactions are characteristically positive in ALL but negative in AML?
• Which of the following is an appropriate screening test for the diagnosis of lupus anticoagulant?
• Which cell type is least likely to be positive for Sudan Black B stain?
• Which test would be abnormal in a patient with factor X deficiency?
• Which factor is involved in the monitoring of heparinized patients through anti-Xa assays?
• What does a high white blood cell count usually indicate in CML?
• A patient presents with an Hct of 30%, hemoglobin of 8 g/dL, and an RBC count of 4.0 × 10^12/L. What is the morphological classification of this anemia?
• In patients with chronic myelocytic leukemia, what is the effect of the Philadelphia chromosome on prognosis?
• Which of the following tests is most likely to be abnormal in patients taking aspirin?
• Which physiological condition best describes the pathophysiology of thrombocytopenia?
• What is the WHO designation for FAB AML M3 under the French-American-British classification?
• Which clotting factors are inhibited by protein S?
• Which phagocytic cells are known to produce lysozymes that exhibit bacteriocidal properties?
• What mechanism leads to hemolysis in hereditary spherocytosis?
• Hypersplenism is characterized by:
• What does the Coulter principle for counting cells rely on?
• Which laboratory test is primarily affected by factor inhibitors?
• Hereditary hemorrhagic telangiectasia is classified as a disorder of which type?
• What is the major type of leukocyte seen in the peripheral smear of a patient with aplastic anemia?
• Which of the following statements is correct regarding the D-dimer test?
• Normal platelet adhesion depends upon which component?
• Fibrin monomers are increased in which of the following conditions?
• Which cell classification is characterized by a positive stain with acid phosphatase that is not inhibited by tartaric acid?
• Waldenström's macroglobulinemia primarily affects which type of cell?
• In primary fibrinolysis, the fibrinolytic activity results in response to:
• Which of the following is NOT associated with the diagnosis of multiple myeloma?
• Which factor deficiency is indicated when APTT corrects after mixing with normal plasma?
• A standard 4.5-mL blue-top tube filled with 3.0 mL of blood was submitted to the laboratory for PT and APTT tests. What is the necessary course of action by the technologist?
• Which antibody is related to paroxysmal cold hemoglobinuria (PCH)?
• Disseminated intravascular coagulation (DIC) is most commonly associated with which type of acute leukemia?
• Which procedure can be modified to measure fibrinogen levels?
• What is the effect of therapeutic phlebotomy on iron levels in polycythemia vera patients?
• Aspirin prevents platelet aggregation by inhibiting which enzyme?
• Which condition is most likely to require monitoring while on low molecular weight heparin (LMWH)?
• What is the significance of the CALLA marker in leukemia diagnosis?
• Which of the following is NOT a feature of secondary polycythemia?
• Which patient groups require monitoring of LMWH therapy?
• What clinical manifestation is commonly seen in hereditary spherocytosis?
• What happens to the PT and APTT when there is excess anticoagulant due to blood volume issues?
• What laboratory finding is characteristic for hemolytic anemias?
• What is the primary purpose of phlebotomy in the treatment of polycythemia vera?
• Which platelet aggregating agent demonstrates a monophasic aggregation curve in optimal concentration?
• A protein that plays a role in both coagulation and platelet aggregation is:
• Which is a characteristic feature of Auer rods?
• Which pathophysiological mechanism does NOT typically contribute to the signs and symptoms of leukemia?
• Which clotting factor is involved in clot formation in vitro but not in vivo?
• Which of the following is not associated with hereditary spherocytosis?
• Given the RBC indices of MCV 88 μm3 (fL), MCH 30 pg, and MCHC 34%, how would the RBCs appear on a peripheral smear?
• Heparin-induced thrombocytopenia (HIT) results from antibodies against which structure?
• What is the preferred anticoagulant for routine coagulation studies?
• What is the role of prostacyclin in hemostasis?
• What is an expected outcome of administering high doses of folate to a patient with vitamin B12 anemia?
• A patient's peripheral smear reveals numerous NRBCs, marked variation of red cell morphology, and pronounced polychromasia. What other CBC parameter may be anticipated?
• What causes erythrocytosis seen in relative polycythemia?
• What does the term leukoerythroblastosis describe in leukemia?
• What is the primary risk associated with hyperhomocysteinemia?
• What is a common finding in aplastic anemia?
• Which hemoglobin is predominantly found in patients with sickle cell trait?
• What is the normal WBC differential lymphocyte percentage range in adults?
• In a patient with dysfibrinogenemia, which test result would be normal?
• Which condition results from the accumulation of leukemic cells in the bone marrow, leading to hematopoietic failure?
• What do you call erythrocytes containing iron granules when stained with Prussian blue?
• Thrombin-thrombomodulin complex is necessary for activation of:
• How does the presence of reticulocytes correlate with red cell production?
• Multiple myeloma is most challenging to differentiate from which of the following?
• What results would be expected in a prothrombin time (PT) and activated partial thromboplastin time (APTT) test for a patient with polycythemia?
• The lupus anticoagulant affects which of the following tests?
• In which condition is Hgb A2 typically elevated?
• What is the preferred method for monitoring heparin therapy during cardiac surgery?
• What defect characterizes Gray's syndrome?
• What condition can lead to the development of DIC?
• What tool is used to count white blood cells manually?
• Which clinical effect is specifically associated with TTP that differentiates it from other disorders?
• Which of the following laboratory findings is characteristic of CML?
• Fletcher factor (prekallikrein) deficiency may be associated with:
• What is a significant feature of neonatal alloimmune thrombocytopenia?
• Which of the following is a characteristic of low molecular weight heparin (LMWH)?
• What inheritance pattern is associated with hemophilia A?
• What type of antibodies are most commonly involved in post-transfusion purpura?
• Which test is primarily used to monitor patients on warfarin therapy?
• Which is the first stage of erythrocytic maturation in which the cytoplasm is pink due to the formation of hemoglobin?
• Reticulocyte production is primarily assessed to evaluate what?
• What potential complication can occur from hypercoagulability associated with HIT?
• What condition will shift the oxyhemoglobin dissociation curve to the right?
• At pH 8.6, which hemoglobin migrates to the same position as Hgb A2?
• Which enzyme is primarily targeted by Argatroban?
• Which laboratory test is affected by heparin therapy?
• In which condition does LAP show the least activity?
• If a patient has increased polychromasia, what additional finding may be expected on the CBC?
• What is the WHO designation for FAB AML M2 according to the French-American-British classification?
• Ecarin clotting time is monitoring which type of therapy?
• Which inclusions are found in leukocytes?
• Which deficiency is commonly noted for causing severe bleeding during surgical procedures?
• Aspirin resistance may be associated with:
• Which characteristic describes antithrombin (AT)?
• What characterizes polycythemia vera (PV)?
• Which is NOT typically associated with multiple myeloma?
• What is the consequence of the APTT test in the presence of lupus anticoagulant?
• What laboratory finding typically differentiates multiple myeloma from Waldenström's macroglobulinemia?
• What is the consequence of having a lupus anticoagulant related to phospholipid-dependent tests?
• Which result on an automated differential suggests that a peripheral smear should be manually reviewed?
• Which of the following is NOT associated with sideroblastic anemia?
• In von Willebrand's disease, which factor also becomes decreased?
• What is the required blast count percentage for diagnosing AML according to the WHO classification?
• A 50-year-old man has been on heparin for the past 7 days. Which combination of the tests is expected to be abnormal?
• Normal PT and APTT results in a patient with poor wound healing may be associated with:
• Congenital dyserythropoietic anemias (CDAs) are primarily characterized by which feature?
• What is the effect of adding sodium fluoride to the naphthyl ASD acetate (NASDA) esterase reaction?
• Which of the following prevents platelet aggregation?
• What is the major consequence of the amino acid change associated with Hgb S?
• Which of the following is correct regarding the international normalized ratio (INR)?
• What is commonly observed in bone marrow slides of patients diagnosed with acute myeloid leukemia?
• Which test result is typically normal in a patient with classic von Willebrand's disease?
• Which condition is often related to the development of thrombocytopenia?
• What type of drugs are warfarin and heparin classified as?
• When thrombin time is prolonged, which condition may be suspected?
• What is a key characteristic finding in the peripheral smear of a patient with multiple myeloma?
• The role of vitamin K is primarily related to the synthesis of which factors?
• Iron deficiency anemia is characterized by which of the following?
• Prolonged APTT readings render which screening test invalid?
• Thrombocytopenia may be associated with what condition?
• Spherocytes differ from normal red cells in all of the following except:
• Which hemoglobin variant shows the slowest mobility at pH 8.6?
• What is the role of thrombin in the coagulation cascade?
• Which condition is most likely associated with autosplenectomy?
• The anemia seen in sickle cell disease is usually:
• Which drug promotes fibrinolysis?
• Sickle cell disorders fall under which category regarding red blood cell defects?
• What is the function of tissue plasminogen activator (tPA)?
• Which of the following drugs inhibits ADP mediated platelet aggregation?
• All of the following are true characteristics of megaloblastic anemia EXCEPT:
• Which of the following tests is primarily abnormal in patients with von Willebrand disease?
• In patients with acute lymphoblastic leukemia, which cell type is likely to be present?
• In thalassemia major, what is the basic hematological defect?
• If a patient's bone marrow shows 70% blasts that are negative for Sudan Black B, what is the likely diagnosis?
• A prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient?
• A decreased osmotic fragility test is typically associated with which condition?
• In which condition would an autohemolysis test yield a positive result?
• After making a 1:200 dilution and counting 336 red cells in 0.2 mm², what is the RBC count?
• What does an increased central pallor in erythrocytes signify?
• What staining method is commonly used for staining and counting reticulocytes?
• What does the anti-Xa heparin assay measure?
• Which electrophoretic pattern is indicative of sickle cell trait?
• What characterizes classic hemophilia A?
• Which staining method is typically used to identify myeloblasts?
• Which condition is characterized by a low LAP score compared to a high LAP score in leukemoid reactions?
• Which treatment is primarily used for managing symptoms in polycythemia vera?
• Which laboratory result would you expect in a patient with afibrinogenemia?
• What finding is typically seen in the peripheral blood smear of a patient with obstructive liver disease?
• What is commonly observed in the peripheral blood smear of a patient with HIV infection?
• What defines Waldenström's macroglobulinemia as a malignancy?
• What condition is characterized by a low concentration of monoclonal protein and no osteolytic lesions?
• Which statement about Coumadin (warfarin) is accurate?
• Which of the following is NOT a common finding in chronic myelogenous leukemia?
• What factor is most commonly associated with hemophilia A?
• What characteristic defines vitamin K?
• Which stain is used to selectively identify phospholipids in myeloid cells?
• Why is a correction necessary for WBC counts when nucleated RBCs are present?
• Which protein is the primary inhibitor of the fibrinolytic system?
• Which leukemia is included in the 2008 WHO classification of myeloproliferative neoplasms?
• Which factor may interfere with the activated protein C resistance (APCR) screening test?
• Which of the following may be associated with thrombotic events?
• Which factor initiates in vivo coagulation by activating factor VII?
• Which symptom is commonly seen in CML but not in acute myeloid leukemia?
• Which of the following clotting factors are activated by thrombin that is generated by tissue pathway (TF-VIIa)?
• How can iron deficiency anemia be distinguished from anemia of chronic infection?
• Which disorder is consistent with normal platelet count, normal PT, and prolonged APTT?
• Which antibody type is used in the D-dimer assay?
• What is the typical hematological presentation of β-thalassemia minor?
• Which pathogen is primarily associated with hemolytic uremic syndrome (HUS)?
• In which of the following conditions is factor V deficiency primarily suspected?
• Which of the following is most commonly associated with activated protein C resistance (APCR)?
• Which anticoagulant's effects are reflected in the activated clotting time test (ACT)?
• What amino acid substitution causes sickle cell anemia?
• Which clotting factor is NOT measured by PT and APTT tests?
• Which of the following drugs is known to be a risk factor for deep venous thrombosis (DVT)?
• Which AML cytogenetic abnormality is associated with acute myelomonocytic leukemia with marrow eosinophilia?
• Plasminogen deficiency is associated with:
• If a 7.0-mL EDTA tube contains only 2.0 mL of blood, which test will likely be erroneous?
• Which type of anemia is commonly associated with chronic kidney disease?
• Which red cell indices are characteristic of megaloblastic anemias?
• What is the primary test used to monitor low molecular weight heparin (LMWH) therapy?
• A falsely elevated Hct will not impact which of the following calculated values?
• Which factor does NOT influence the erythrocyte sedimentation rate (ESR)?
• Which substance do neutrophils release that aids in combating bacterial infections?
• Hereditary pyropoikilocytosis (HP) is a red cell membrane defect characterized by what type of cell morphology?
• Which anemia has red cell morphology similar to that seen in iron deficiency anemia?
• What kind of hematological feature is common in hemolytic uremic syndrome?
• Whose action leads to the increased platelet aggregation seen in acquired TTP?
• An M:E ratio of 10:1 is most commonly associated with which condition?
• Which statistical term is the best index of precision when comparing two CBC parameters?
• Which of the following indirect tests is insensitive to LMWH effects?
• What condition is likely indicated by a low platelet count in a newborn with petechiae and purpura?
• In patients with a factor VIII inhibitor, how does the APTT behave after mixing studies?
• What is the primary hemoglobin type found in patients with thalassemia major?
• In platelet aggregation studies, which result is most likely associated with Bernard-Soulier syndrome?
• What is the osmotic fragility test result in a patient with thalassemia major most likely to be?
• Which clotting factors are measured by the APTT test?
• What type of cells are found in chronic lymphocytic leukemia?
• Lupus anticoagulant is most commonly associated with which condition?
• The APTT test is sensitive to deficiencies of which clotting factor?
• What is the primary purpose of using a Miller disk in a laboratory setting?
• In multiple myeloma, what is often replaced by the production of excessive immunoglobulins?
• Which of the following organs is responsible for the "pitting process" for RBCs?
• Which laboratory results are indicative of DIC?
• Which results are associated with hemophilia A?
• Which disorder is commonly associated with neurological findings?
• Which of the following is considered a normal form of hemoglobin?
• Which substance is contained in the primary granules of neutrophils?
• Which term describes the variation in red cell size observed on a peripheral smear?
• What test is used to monitor heparin therapy?
• Factor XII deficiency is associated with which risk?
• Which of the following cells would most likely be elevated in patients with hemolytic anemia?
• What laboratory test is used to screen for activated protein C resistance?
• What is an unusual complication associated with infectious mononucleosis?
• Autoagglutination of red cells at room temperature can cause which of the following abnormal test results?
• What effect does insufficient centrifugation have on hematocrit (Hct) value?
• An abnormal APTT caused by a pathological circulating anticoagulant is:
• Which type of acute myeloid leukemia is known as true monocytic leukemia?
• What is one consequence of decreased α2-antiplasmin levels in the body?
• What is the best method for determining storage iron?
• What red cell inclusion may be seen in the peripheral blood smear of a patient post-splenectomy?
• Storage pool deficiencies in platelets are primarily due to defects in what?
• In acute megakaryoblastic leukemia, what percentage of the blasts are of megakaryocytic lineage?
• In leukemic lymphoblasts, which type is most characteristically associated with the CALLA antigen?
• What is a major criterion for the 2008 WHO diagnostic criteria for essential thrombocythemia?
• Which factor deficiency would most likely result in prolonged APTT and normal PT?
• What substrate is used in a chromogenic factor assay?
• What is a notable feature in the blood of a patient with chronic myelogenous leukemia?
• Which reagents are used in the PT test?
• What characteristic is typical of autoimmune hemolytic anemia?
• What would be the likely finding in a peripheral blood smear of a patient with megaloblastic anemia?
• Which condition is often associated with a deficiency of vitamin B12?
• What is the treatment of choice for factor VIII deficiency?
• What is indicated by an elevated LAP score in a patient?
• In a peripheral blood smear, what condition reflects abnormal cell shape?
• What is a common consequence of thrombocytopenia?
• Which statement is correct regarding the fibrinogen/fibrin degradation product test?
• In which age group would 60% lymphocytes be considered normal?
• Which type of leukemia primarily affects granulocytic precursors and is sensitive to Sudan Black B staining?
• In a vitamin K-deficient patient, which coagulation test(s) would be abnormal?
• What key pathology is associated with multiple myeloma?
• In a case where 75% of blasts in a peripheral smear stain positive for Sudan Black B and peroxidase, what is the most likely diagnosis?
• What is the hallmark feature of hemolysis seen in PNH?
• What laboratory feature distinguishes hairy cell leukemia?
• Which factor deficiency is characterized by both a prolonged PT and APTT?
• What role do spherocytes play in the context of hemolytic anemia?
• What test is commonly used to monitor warfarin therapy?
• The P2Y12 ADP receptor agonist assay is useful for monitoring which of the following drugs?
• Which of the following statements about osteoclasts is true regarding multiple myeloma?
• What does an increase in INR indicate in a patient on warfarin therapy?
• The morphological classification of anemias primarily relies on which parameter?
• Repeated phlebotomy in patients with polycythemia vera (PV) may lead to the development of which condition?
• How is Mean Cell Volume (MCV) calculated?
• Acquired thrombotic thrombocytopenic purpura (TTP) is characterized as what type of disease?
• What is the significance of increased 2,3 DPG levels in red blood cells?
• What is a primary characteristic of acute immune thrombocytopenic purpura?
• What condition is indicated by a false increase in hematocrit?
• Thrombophilia is most closely associated with which condition?
• What is the calculation method for determining the LAP score from a given leukocyte alkaline phosphatase stain?
• Which set of red blood cell indices suggests spherocytosis?
• What is the expected laboratory data for a patient suffering from pernicious anemia?
• In a blood sample, a raised MCHC might indicate what condition?
• What effect does refrigeration have on PT samples longer than 24 hours?
• Which cells are pathognomonic for Hodgkin's disease?
• What is the nature of paroxysmal nocturnal hemoglobinuria (PNH)?
• What is the shape of macrocytes typically seen in megaloblastic processes?
• Which of the following disorders has an increase in osmotic fragility?
• Which laboratory finding is indicative of thrombocytopenia in leukemia patients?
• Which anticoagulant drug can be safely used in patients with HIT?
• In essential thrombocythemia, how do the platelets typically present?
• Which of the following is NOT associated with intravascular hemolysis?
• What is the role of the spleen in relation to red blood cells?
• In which age group is acute lymphoblastic leukemia most frequently diagnosed?
• What is the mean cell hemoglobin concentration (MCHC) if Hgb is 15 g/dL and Hct is 47 mL/dL?
• What additional feature is considered in the WHO classification of myelo- and lymphoproliferative disorders?
• Which statement regarding protein C is correct?
• What happens to PT results if a tube with insufficient blood volume is submitted?
• Which condition leads to abnormal platelet aggregation tests?
• If a laboratory report shows a high percentage of blasts, what condition is most indicative of acute erythroid leukemia?
• Thrombotic thrombocytopenic purpura (TTP) is characterized by which of the following?
• What is the primary effect of warfarin?
• The most common subtype of classic von Willebrand's disease is:
• What is the mechanism behind post-transfusion purpura (PTP)?
• How is the reticulocyte count expressed in anemic patients?
• What impact does using a buffer at pH 6.0 have on a Wright's-stained smear?
• In which condition are "bite cells" commonly observed?
• What clinical condition likely caused a prolonged PT that corrected with intravenous vitamin K after 24 hours?
• What would be the most likely classification by the WHO for FAB AML M7 according to the French-American-British classification?
• Which chronic myeloproliferative disorder is NOT associated with the JAK2(V617F) mutation?
• In the context of blood disorders, what does "pancytopenia" refer to?
• Which instrument can be utilized to evaluate platelet function?
• What is a common finding in the peripheral blood of patients with essential thrombocythemia?
• Which condition is typically characterized by an increased reticulocyte count?
• A clinical feature unique to severe von Willebrand's Disease is?
• What is characteristically seen in the peripheral blood of patients with polycythemia vera?
• Which set of platelet responses would be most likely associated with Glanzmann's thrombasthenia?
• Which test is most diagnostic for confirming iron deficiency anemia?
• Diagnosis of lupus anticoagulant is confirmed by which of the following criteria?
• Which anemia is noted for a lack of intrinsic factor that prevents B12 absorption?
• What condition demonstrates prolonged APTT with no correction after mixing studies?
• Which of the following abnormalities is consistent with the presence of lupus anticoagulant?
• Which parameter may be similar in anemia of inflammation and iron deficiency anemia?